No independent candidate has ever been on an Indiana government-printed ballot for either U.S. Senate or Governor. Businessman Nathan Altman will attempt to get on the ballot this year for U.S. Senate. See this story.
No minor party or independent candidate petition for statewide office has succeeded in Indiana since 2000. Indiana is one of only four states in which Ralph Nader never got on the ballot, even though he is the person who placed third in 2000, 2004, and 2008.